現(xiàn)貨moradec AM-106-PB說(shuō)明書
αMFc CL PBD
具有可裂解連接子的抗小鼠IgG Fc PBD抗體
目錄號(hào)：AM-106-PB
αMFc CL PBD是抗小鼠IgG Fc特異性抗體，與吡咯并二氮雜平（PBD）結(jié)合，具有可裂解接頭?？贵w部分是對(duì)小鼠IgG的Fc區(qū)具有特異性的多克隆抗體，并且它也對(duì)大鼠IgG的Fc區(qū)具有交叉反應(yīng)性。吡咯并二氮卓（PBD）是一種細(xì)胞毒性小分子，它與DNA小凹槽結(jié)合，并與DNA的特定位點(diǎn)交叉連接。連接PBD和抗體的可裂解接頭在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過內(nèi)吞作用進(jìn)入細(xì)胞，就會(huì)被內(nèi)體中的組織蛋白酶裂解。
| Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AM-106-PB |
| αMFc-CL-PBD is anti-mouse IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs, and it is also cross-reactive to the Fc region of Rat IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
